Nowadays, Overweight is a widespread problem which is growing due to the quality of food and contemporary tendency in nutrition characterized by irregular and improper meals. A lot of medicines supporting weight loss achieved by physical exercises and diets have been created to solve the problem more efficiently. Their main aim is to improve and keep the result, but still there are some differences. Here we are going to consider Phentermine and Sibutramine – two weight loss drugs, which are rather popular and often prescribed by dietitians.
Phentermine and Sibutramine are two weight loss drugs, prescribed as a supplement to a diet therapy and regular physical exertion. The only difference is that Phentermine is meant for a short-term use, 12 weeks maximum. While Sibutramine can be used for weight loss within a year.
Both these weight loss drugs are prescribed for management of exogenous obesity in patients with BMI of or more than 30, as well as those, whose BMI is above 27 but accompanied by other risk factors (in particular: hypertension, diabetes mellitus and hyperlipidemia).
Mechanism of Action
Phentermine and Sibutramine help to lose weight by suppressing appetite. Phentermine belongs to the drug class of amphetamines. Phentermine effect is manifested by acting on norepinephrine neurotransmitter in the brain, which is responsible for satiety. Sibutramine s a serotonin-norepinephrine reuptake inhibitor (SNRIs).
Although therapeutic action of Sibutramine is associated with amphetamine, its mechanism of action is different from Phentermine. Unlike Phentermine, which inhibits the release of neurotransmitters, Sibutramine acts on the reuptake of neurotransmitters. Thus, Sibutramine reduces the reuptake of dopamine by 16%, serotonin by 53% and norepinephrine by 54%.
There is age limit for taking both of these drugs. Usually, a patient must be older than 18 and younger than 65. If you don’t belong to the age group from 18 to 65, these medicines are contraindicated. Other contraindications include the following:
- Cardiovascular diseases
- Drug and alcohol abuse
- Depressive disorders
- Hypersensitivity to any ingredient.
Like most of drugs, Phentermine and Sibutramine have some side effects, and it’s necessary to be aware of what the medicination’s action may be accompanied with. There are some possible common side effects for Phentermine and Sibutramine:
- Dry mouth
- Swelling of the legs and ankles
- Heart palpitation
- Chest pain.
Moreover, there are some individual side effects for each drug, which are caused by difference in the nature of their action. The application of the weight loss drugs Phentermine and Sibutramine along with a low-calorie diet and physical activity helps to reduce the weight loss several times faster.
In order to buy Phentermine and Sibutramine online, you don’t have to fill out medical questionnaire. Thus, you can order Sibutramine and Phentermine with no prescription in just 3-5 minutes.